Vaccine Excipient & Media
Summary
Excipients Included in U.S. Vaccines, by Vaccine
This table includes not only vaccine ingredients (e.g.,
adjuvants and preservatives), but also substances used during the manufacturing
process, including vaccineproduction media, that are removed from the final
product and present only in trace quantities. In addition to the substances
listed, most vaccines contain Sodium Chloride (table salt).
Last Updated February 2012
All reasonable efforts have been made to ensure the
accuracy of this information, but manufacturers may change product contents
before that information is reflected here. If in doubt, check the
manufacturer’s package insert.
Vaccine
|
Contains
|
Source: Manufacturer’s P.I.
Dated
|
Adenovirus
|
sucrose, Dmannose, Dfructose, dextrose, potassium
phosphate, plasdone C, anhydrous lactose, micro crystalline cellulose,
polacrilin potassium, magnesium stearate, cellulose acetate phthalate,
alcohol, acetone, castor oil, FD&C Yellow #6 aluminum lake dye, human
serum albumin, fetal bovine serum, sodium bicarbonate, humandiploid
fibroblast cell cultures (WI38), Dulbecco’s Modified Eagle’s Medium
|
March, 2011
|
Anthrax (Biothrax)
|
aluminum hydroxide, benzethonium chloride,
formaldehyde, amino acids, vitamins, inorganic salts and sugars
|
December, 2008
|
BCG (Tice)
|
glycerin, asparagine, citric acid, potassium
phosphate, magnesium sulfate, Iron ammonium citrate, lactose
|
February, 2009
|
DT (Sanofi)
|
aluminum potassium sulfate, peptone, bovine
extract, formaldehyde, thimerosal (trace), modified Mueller and Miller medium
|
December, 2005
|
DTaP (Daptacel)
|
aluminum phosphate, formaldehyde,
glutaraldehyde, 2Phenoxyethanol, StainerScholte medium, modified Mueller’s
growth medium, modified MuellerMiller casamino acid medium (without beef
heart infusion)
|
July, 2011
|
DTaP (Infanrix)
|
formaldehyde, glutaraldehyde, aluminum
hydroxide, polysorbate 80, Fenton medium (containing bovine extract),
modified Latham medium (derived from bovine casein), modified StainerScholte
liquid medium
|
November, 2011
|
DTaP (Tripedia)
|
sodium phosphate, peptone, bovine extract (U.S.
sourced), formaldehyde, ammonium sulfate, , aluminum potassium sulfate,
thimerosal (trace), gelatin, polysorbate 80 (Tween 80), modified Mueller and
Miller medium, modified StainerScholte medium
|
December, 2005
|
DTaPIPV (Kinrix)
|
formaldehyde, glutaraldehyde, aluminum
hydroxide, Vero (monkey kidney) cells, calf serum, lactalbumin hydrolysate,
polysorbate 80, neomycin sulfate, polymyxin B, Fenton medium (containing
bovine extract), modified Latham medium (derived from bovine casein),
modified StainerScholte liquid medium
|
November, 2011
|
DTaPHepBIPV (Pediarix)
|
formaldehyde, gluteraldehyde, aluminum
hydroxide, aluminum phosphate, lactalbumin hydrolysate, polysorbate 80,
neomycin sulfate, polymyxin B, yeast protein, calf serum, Fenton medium
(containing bovine extract), modified Latham medium (derived from bovine
casein), modified StainerScholte liquid medium, Vero (monkey kidney) cells
|
November, 2011
|
DTaPIPV/Hib (Pentacel)
|
aluminum phosphate, polysorbate 80,
formaldehyde, gutaraldehyde, bovine serum albumin, 2phenoxethanol, neomycin,
polymyxin B sulfate, Mueller’s Growth Medium, MuellerMiller casamino acid
medium (without beef heart infusion), StainerScholte medium (modified by the
addition of casamino acids and dimethylbetacyclodextrin), MRC5 (human
diploid) cells, CMRL 1969 medium (supplemented with calf serum).
|
July, 2011
|
Hib (ActHIB)
|
ammonium sulfate, formalin, sucrose, Modified
Mueller and Miller medium
|
May, 2009
|
Hib (Hiberix)
|
formaldehyde, lactose.
|
December, 2010
|
Hib (PedvaxHIB)
|
aluminum hydroxphosphate sulfate.
|
December, 2010
|
Vaccine
|
Contains
|
Source: Manufacturer’s P.I. Dated
|
Hib/Hep B (Comvax)
|
yeast (vaccine contains no detectable yeast DNA),
nicotinamide adenine dinucleotide, hemin chloride, soy peptone, dextrose,
mineral salts, amino acids, formaldehyde, potassium aluminum sulfate,
amorphous aluminum hydroxyphosphate sulfate, sodium borate
|
December,
2010
|
Hep A (Havrix)
|
aluminum hydroxide, amino acid supplement,
polysorbate 20, formalin, neomycin sulfate, MRC5 cellular proteins
|
July,
2011
|
Hep A (Vaqta)
|
amorphous aluminum hydroxyphosphate sulfate,
bovine albumin, formaldehyde, neomycin, sodium borate, MRC5 (human diploid) cells
|
December,
2010
|
Hep B (EngerixB)
|
aluminum hydroxide, yeast protein, phosphate
buffers.
|
October,
2011
|
Hep B (Recombivax)
|
yeast protein, soy peptone, dextrose, amino
acids, mineral salts, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate
sulfate, formaldehyde.
|
July,
2011
|
Hep A/Hep B (Twinrix)
|
formalin, yeast protein, aluminum phosphate,
aluminum hydroxide, amino acids, phosphate buffer, polysorbate 20, neomycin
sulfate, MRC5 human diploid cells
|
November,
2011
|
Human Papillomavirus (HPV) (Cerverix)
|
vitamins, amino acids, lipids, mineral salts,
aluminum hydroxide, sodium dihydrogen phosphate dehydrate, insect cell and
viral protein..
|
July,
2011
|
Human Papillomavirus (HPV) (Gardasil)
|
yeast protein, vitamins, amino acids, mineral
salts, carbohydrates, amorphous aluminum hydroxyphosphate sulfate, Lhistidine,
polysorbate 80, sodium borate.
|
March,
2011
|
Influenza (Afluria)
|
betapropiolactone, thimerosol (multidose
vials only), monobasic sodium phosphate, dibasic sodium phosphate, monobasic
potassium phosphate, potassium chloride, calcium chloride, sodium
taurodeoxycholate, neomycin sulfate, polymyxin B, egg protein
|
November
2011
|
Influenza (Fluarix)
|
sodium deoxycholate, formaldehyde, octoxynol10
(Triton X100), tocopheryl hydrogen succinate, polysorbate 80 (Tween 80),
hydrocortisone, gentamicin sulfate, ovalbumin
|
April,
2011
|
Influenza (Fluvirin)
|
nonylphenol ethoxylate, thimerosal (multidose
vial–trace only in prefilled syringe), polymyxin, neomycin, betapropiolactone,
egg proteins
|
May,
2011
|
Influenza (Flulaval)
|
thimerosal, tocopheryl hydrogen succinate,
polysorbate 80, formaldehyde, sodium deoxycholate, ovalbumin
|
December,
2011
|
Influenza (Fluzone: Standard, HighDose, &
Intradermal)
|
formaldehyde, octylphenol ethoxylate (Triton X100),
sodium phosphate, gelatin (standard formulation only), thimerosal (multidose
vial only) , egg protein
|
May,
2011
|
Influenza (FluMist)
|
ethylene diamine tetraacetic acid (EDTA),
monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic
potassium phosphate, monobasic potassium phosphate, gentamicin sulfate, egg
protein
|
May,
2011
|
Japanese Encephalitis (Ixiaro)
|
aluminum hydroxide, Vero cells, protamine
sulfate, formaldehyde, bovine serum albumin, sodium metabisulphite.
|
September,
2010
|
Meningococcal (MCV4Menactra)
|
formaldehyde, phosphate buffers, Mueller Hinton
agar, Watson Scherp media, Modified Mueller and Miller medium
|
November,
2011
|
Meningococcal (MCV4Menveo)
|
formaldehyde, amino acids, yeast extract, Franz
complete medium
|
March,
2011
|
Meningococcal (MPSV4Menomune)
|
thimerosal (multidose vial only), lactose,
Mueller Hinton agar, Watson Scherp media
|
January,
2009
|
MMR (MMRII)
|
vitamins, amino acids, fetal bovine serum, sucrose,
sodium phosphate, glutamate, recombinant human albumin, neomycin, sorbitol,
hydrolyzed gelatin, chick embryo cell culture, WI38 human diploid lung
fibroblasts
|
December,
2010
|
MMRV (ProQuad)
|
sucrose, hydrolyzed gelatin, sorbitol,
monosodium Lglutamate, sodium phosphate dibasic, human albumin, sodium
bicarbonate, potassium phosphate monobasic, potassium chloride, potassium
phosphate dibasic, neomycin, bovine calf serum, chick embryo cell culture, WI38
human diploid lung fibroblasts, MRC5 cells
|
August,
2011
|
Pneumococcal (PCV13 – Prevnar 13)
|
casamino acids, yeast, ammonium sulfate,
Polysorbate 80, succinate buffer, aluminum phosphate
|
January,
2012
|
Vaccine
|
Contains
|
Source: Manufacturer’s P.I. Dated
|
Pneumococcal (PPSV23 – Pneumovax)
|
phenol.
|
October,
2011
|
Polio (IPV – Ipol)
|
2phenoxyethanol, formaldehyde, neomycin,
streptomycin, polymyxin B, monkey kidney cells, Eagle MEM modified medium,
calf serum protein
|
December,
2005
|
Rabies (Imovax)
|
albumin, neomycin sulfate, phenol, MRC5 human
diploid cells
|
December,
2005
|
Rabies (RabAvert)
|
propiolactone, potassium glutamate, chicken
protein, ovalbumin, neomycin, chlortetracycline, amphotericin B, human serum
albumin, polygeline (processed bovine 14 gelatin)
|
October,
2006
|
Rotavirus (RotaTeq)
|
sucrose, sodium citrate, sodium phosphate
monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media,
fetal bovine serum, vero cells [DNA from porcine
circoviruses (PCV) 1 and 2 has been detected in RotaTeq. PCV1 and PCV2 are
not known to cause disease in humans.]
|
September,
2011
|
Rotavirus (Rotarix)
|
amino acids, dextran, , sorbitol, sucrose,
calcium carbonate, xanthan, Dulbecco’s Modified Eagle
Medium (DMEM) [Porcine circovirus type 1 (PCV1) is present
in Rotarix. PCV1 is not known to cause disease in humans.]
|
February,
2011
|
Smallpox (Vaccinia – ACAM2000)
|
human serum albumin, mannitol, neomycin,
glycerin, polymyxin B, phenol, Vero cells
|
August,
2007
|
Td (Decavac)
|
aluminum potassium sulfate, peptone, formaldehyde,
thimerosal, bovine muscle tissue (US sourced), Mueller and Miller medium,
|
March,
2011
|
Td (Tenivac)
|
aluminum phosphate, formaldehyde, modified
MuellerMiller casamino acid medium without beef heart infusion
|
December,
2010
|
Td (Mass Biologics)
|
aluminum phosphate, formaldehyde, thimerosal
(trace), ammonium phosphate, modified Mueller’s media (containing bovine
extracts)
|
February,
2011
|
Tdap (Adacel)
|
aluminum phosphate, formaldehyde,
glutaraldehyde, 2phenoxyethanol, ammonium sulfate, Mueller’s
growth medium, MuellerMiller casamino acid medium (without beef heart
infusion)
|
December,
2010
|
Tdap (Boostrix)
|
formaldehyde, glutaraldehyde, aluminum
hydroxide, polysorbate 80 (Tween 80), Latham medium derived from bovine
casein, Fenton medium containing a bovine extract, StainerScholte liquid
medium
|
January,
2012
|
Typhoid (inactivated – Typhim Vi)
|
hexadecyltrimethylammonium bromide, phenol,
polydimethylsiloxane, disodium phosphate, monosodium phosphate
|
December,
2005
|
Typhoid (oral – Ty21a)
|
yeast extract, casein, dextrose, galactose,
sucrose, ascorbic acid, amino acids
|
August,
2006
|
Varicella (Varivax)
|
sucrose, phosphate, glutamate, gelatin,
monosodium Lglutamate, sodium phosphate dibasic, potassium phosphate
monobasic, potassium chloride, sodium phosphate monobasic, EDTA, residual
components of MRC5 cells including DNA and protein, neomycin, fetal bovine
serum, human diploid cell cultures
|
August,
2011
|
Yellow Fever (YFVax)
|
sorbitol, gelatin, egg protein
|
January,
2010
|
Zoster (Shingles – Zostavax)
|
sucrose, hydrolyzed porcine gelatin, monosodium
Lglutamate, sodium phosphate dibasic, potassium phosphate monobasic,
neomycin, potassium chloride, residual components of MRC5 cells including
DNA and protein, bovine calf serum
|
June,
2011
|
A table listing vaccine excipients and media by
excipient can be found in:
Grabenstein JD. ImmunoFacts:
Vaccines and Immunologic Drugs – 2012 (37th revision).
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